TA-100

DESCRIPTION
Testosterone Base is raw steroid with no ester attached to it, which gives pure raw testosterone as it only contains. The men who lac testosterone in the body use this solution for the growth and development of the testes and prostate. Along with which it also promotes and increase in muscle and bone mass. Testosterone base comes in a water based aqueous form suspension.

CLINICAL PHARMACOLOGY
TA-100 is aqua suspension-based injectable testosterone. Testosterone Base is having anabolic as well as androgenic properties. The Suspension esters has shorter half life compared to cypionate & enanthate esters. Testosterone suspension has a duration of effect of 1 to 2 days. Therefore Testosterone Suspension is much faster acting than other testosterone esters such as cypionate orenanthate. Suspension is only a quickly effective testosterone that must be injected more often, and requires a much more frequent dosing schedule in order to maintain stable blood levels, Testosterone is 98% bound to a specific testosterone-estradiol binding globulin in plasma, and about 2% is free and about 90% of a dose of testosterone is excreated in the urine as glucuronic and sulphuric acid ie., conjugates of testosterone and its metabolites, about 6% of a dose is excreated in the faces, mostly in the conjugated form. Inactivation of testosterone occurs primarily in the liver.

INDICATIONS AND USAGE
Male:
Testicular failure: hypogonadal disorders, eunuchiodism, endocrine impotence. hypopituitarism, loss of libido, delayed puberty, osteoporosis, infertility due to disorders of spermatogenesis, Male climacteric symptoms, hereditary angioneurotic oedema.
Female:
Genital carcinoma, Endometriosis, fibroids, breast carcinoma, menopausal syndrome.

CONTRAINDICATIONS
Carcinoma of the male breast
Carcinoma known or suspected of the prostate.
Cardiac, hepatic or renal impairment.
Hypercalcemia.
Prepubertal males.
Hypersensitivity to testosterone orany other excipients
Pregnancy and feeding mothers as testosterone esters causes fetal harm.

SIDE EFFECTS AND PRECAUTIONS
Testosterone Base, when administered in the body, is partially converted to both estrogen as well as Di-hydrotestosterone. These are often the cause of many side effects such as gynocomastia, water retention, hair loss and prostate enlargement. Also, as with most steroids, injected testosterone propionate will inhibit natural testosterone levels and PTA (Hypothalamic Pituitary Testicular Axis).
The advantage with testosterone base, in this respect, is that it will clear your system more quickly than other esters, and allow you to begin recovery more rapidly. If there is a predisposition and very high dosages are taken, the known androgenic-linked side effects such as acne vulgaris, accelerated hair loss, and increased growth of body hair and deep
voice can occur. The toxic influence on the liver is minimal so that a liver damage is unlikely compared to enanthate esters. An increased libido is common both in men and women with the use of TA-100. Testosterone base aqua suspension is a more painful injection, pronounced soreness and low-grade fever that may last for a few days, with swelling and noticeable pain around the injection site.

DRUG INTERACTIONS
Anticoagulant Testosterone may potentate the effects of anticoagulant.
Antidiabetic agents & Insulin: may reduce the blood glucose level & insulin in diabetic patients.
Oxyphenbutazon: concurrent administration of Oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone Rifampicin and Phenobarbitone may increase rate of metabolism.

DOSAGE AND DIRECTIONS FOR USE
Testosterone Base Aqua Suspension should be administered intramuscularly. The most common dosage is 50 to 100mg, every day or 2nd day and total weekly dosage would be in the range of 300-400mg.
Females: 50-100 mg three times in a week for the treatment of breast cancer in women.

HOW SUPPLIED
TA-100, 100 mg per mL is available in vials of 1 mL. in cartons of 10. Store at 20° to 25°C (68° to 77°F). PROTECT FROM LIGHT. Store in carton until contents are used.