PR-100

DESCRIPTION

PR-100 is a steroid compound that is described chemically as 17(3-Hydroxy-1 -methyl- 5 a-androst-1 -en-3 -one heptanoate. PR-100 is a sterile solution of Methenolone Enanthate. By considering its anabolic to androgenic ratio, users will be able to conclude that the steroid is quite mild but is still efficient in different uses – as compared to Drostanolone because Methenolone Enanthate has higher androgenic (testosterone replacements) and anabolic (muscle growth) effects. The drug can be taken in both injectable and oral form.

CLINICAL PHARMACOLOGY
In aplastic anemias of various origins – both the idiopathic forms and those with exogenously damaged bone marrow – high doses of Methenolone Enanthate may stimulate bone marrow function, particularly erythropoiesis.

INDICATIONS AND USAGE
1. Aplastic anemias. The therapy may have to be continued for at least 3 months at a dosage of 200-300 mg per week. Since some patients only respond after several months, treatment must not be stopped too soon. After improvement of the clinical picture treatment should, as a general rule, be continued for a further few weeks. Deterioration of the blood count after discontinuation of therapy may be reversed by renewed administration of PR-100
2. Osteoporosis.
3. Progressive breast cancer

CONTRAINDICATIONS
PR-100 Injection is contra-indicated in pregnancy as the Methenolone Enanthate contained in the preparation, like all anabolic agents, possesses some androgenic activity which may lead to signs of virilization in the female newborn.
Because of this androgenic activity, PR-100 Injection is also contra-indicated in patients with prostatic carcinoma, since such substances may aggravate the disease.

SIDE EFFECTS AND SPECIAL PRECAUTIONS
Side effects with PR-100 are minimal and manifest themselves only rarely and in persons who are extremely sensitive. Due to the androgenic residual effect, side effects include light acne, deep voice or increased hair growth. PR-100 has even less influence on the liver function than the oral form so that an increase of the liver toxicity values is extremely unlikely. The blood pressure, cholesterol level, HDL and LDL values, as with PR-100 tablets, usually remain unaffected. PR-100 is generally the safest injectable steroid.
In female patients, signs of virilization (acne, hirsutism, deepening of the voice) must be reckoned with; in sexually mature women irregularities may occur.
In adult males, spermatogenesis may be inhibited, in boys there may be signs of puberty.

ADVERSE REACTIONS
The following adverse reactions in the male have occurred with some androgens:
Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erection. Oligospermia may occur at high dosages.
Skin and appendages: Hirsutism, male pattern of baldness, seborrhea, and acne.
Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatic
Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.

DOSAGE AND ADMINISTRATION
PR-100 is for intramuscular use only. It should not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle
Aplastic anemia: The therapy may have to be continued for at least 3 months at a dosage of 200-300 mg per week.
Osteoporosis: The suggested dosage is 100 mg every 2 weeks, reducing to once every 3 to 4 weeks after an initial response.
Progressive breast cancer: 100 mg every 1 to 2 weeks, or 200 mg every 2 to 3 weeks.
Body Building: effectively injection dose: male 350-600 mg per week and female 100 mg per week.

How is Supplied
PR-100 (Methenolone Enanthate) Injection USP, 100 mg per mL is available in vials of 1 mL, in cartons of 10. Store at 20° to 25°C (68° to 77°F). PROTECT FROM LIGHT. Store in carton until contents are used.